I fixed this by removing both panels, probably would work just by removing one of them, but I don't have time right now to mess with it. Since other pages have updatepanels I'm guessing it's because these two are nested or something else (update conditional?) i dunno, just happy to have it working
I opened a bug report with Apple (it's the same on PC or Mac Safari) and I tried to open a case with AbleCommerce but it didn't seem to go through.
Here is my build info
PLATFORM: ASP.NET
VERSION: 7.0
BUILD: 10125
AjaxControlToolkit: 1.0.10301.0
barcode_web: 1.0.0.0
BarcodeLib: 1.0.0.0
CommerceBuilder: 7.0.10110.0
CommerceBuilder.AuthorizeNet: 7.0.9764.0
CommerceBuilder.CanadaPost: 7.0.0.0
CommerceBuilder.CCH: 7.0.0.0
CommerceBuilder.Configuration: 7.0.10102.0
CommerceBuilder.CyberSource: 7.0.9764.0
CommerceBuilder.DataClient.Api: 1.0.0.21
CommerceBuilder.DataClient.Csv: 1.0.0.0
CommerceBuilder.DHL: 7.0.8825.0
CommerceBuilder.ECB: 7.0.0.0
CommerceBuilder.FedEx: 7.0.9725.0
CommerceBuilder.FRBNY: 7.0.0.0
CommerceBuilder.GoogleCheckout: 7.0.10052.0
CommerceBuilder.InternetSecure: 7.0.9764.0
CommerceBuilder.LinkPoint: 7.0.9764.0
CommerceBuilder.MercuryPayment: 1.0.0.0
CommerceBuilder.Paradata: 7.0.9764.0
CommerceBuilder.PayFlowPro: 7.0.10061.0
CommerceBuilder.PayJunction: 7.0.9764.0
CommerceBuilder.PayPal: 7.0.10071.0
CommerceBuilder.PlugNPay: 7.0.0.0
CommerceBuilder.Services: 7.0.9733.0
CommerceBuilder.SkipJack: 7.0.9764.0
CommerceBuilder.UPS: 7.0.10041.0
CommerceBuilder.USPS: 7.0.9728.0
CommerceBuilder.Web: 7.0.9777.0
ComponentArt.Web.UI: 2007.1.1566.3
CyberSource.Base: 2.0.0.0
CyberSource.Clients: 5.0.2.0
CyberSource.Clients.XmlSerializers: 5.0.2.0
CyberSource.WSSecurity: 2.0.0.0
CybsWSSecurityIOP: 1.0.0.0
edtFTPnet: 1.2.4.0
FlashMovie: 1.0.3084.18534
FredCK.FCKeditorV2: 2.5.2912.21007
ICSharpCode.SharpZipLib: 0.85.1.271
LinkPointTransaction: 1.0.1797.29766
log4net: 1.2.10.0
Microsoft.Practices.EnterpriseLibrary.Common: 2.0.0.0
Microsoft.Practices.EnterpriseLibrary.Data: 2.0.0.0
Microsoft.Practices.ObjectBuilder: 1.0.51205.0
Microsoft.Web.Preview: 1.2.61025.0
NVelocity: 7.0.8530.0
PaygatewayNET: 3.0.0.0
paypal_base: 4.2.1.0
PFProCOMLib: 1.0.0.0
PFProdotNET: 0.0.0.0
r2pMercuryGCardPlus: 1.0.0.0
Twitterizer.Framework: 1.0.0.0
Validators: 1.0.0.0
WebChart: 1.1.1.6
wwHoverPanel: 1.85.0.0